Posts

A cancer doctor speaking to a room of students.

Who wants to be a doctor?

We join forces with Ullern Upper Secondary School and Oslo University Hospital every year to arrange theme days for students, so they can get a sense of what it is like to be a doctor.

On 18 November 2019, students from the health program with specialisation in biology and chemistry at Ullern Upper Secondary School, gathered in Kaare Norum Auditorium at Oslo Cancer Cluster Innovation Park to learn more about opportunities in medicine. The initiator is Truls Ryder, father of a former student at the school. Ryder is a surgeon at the Norwegian Radium Hospital and has this year once again planned theme days for the students together with his colleagues.

For almost five hours, the Ullern students listened to some of the best oncologists in Norway talk about how they treat cancer patients affected by different forms of cancer. The students are studying either science or health subjects in their third year.

The theme day is a part of the close collaboration between Ullern Upper Secondary School and the Norwegian Radium Hospital, Oslo University Hospital. For two days, 18 of the students who consider applying to medical or nursing school will follow the oncologists around the different departments of the Norwegian Radium Hospital.

“The students who have been chosen to job shadow are in their last year and will soon choose their next program of study,” Bente Prestegård said. She is the project manager for the school collaboration between Ullern Upper Secondary School and Oslo Cancer Cluster.

The purpose of the job shadowing is that students who participate will get an inside look into the opportunities that exist in medical subjects before choosing what to study next.

A fantastic initiative

Truls Ryder is the initiator behind the theme day and the following job shadowing, like he was last year. His children have gone to Ullern Upper Secondary School and he works as an attending physician at the Norwegian Radium Hospital.

“Thank you to the initiator Truls Ryder and his colleagues who have dedicated two days for this. It was really successful last year and we are incredibly happy to be able to offer the students this opportunity again,” Prestegård said.

Prestegård has contributed to the planning of the theme days with her long experience from other projects between members of Oslo Cancer Cluster and the school.

You can read about last year’s theme day and job shadowing here.

A varied program

The theme day today was spent in Kaare Norums Auditorium from 11:30 am to 4:00 pm. During these hours, the students have gained an in-depth introduction to modern cancer treatments, from radiology to plastic surgery, and what it is like to be a cancer patient and receive treatment.

“I look forward to the program myself, because there are many skilled experts, who will present what they do in cancer treatment and more. The goal with such a broad program is to give the students the greatest possible understanding of all the different directions and opportunities that medical study can offer,” said Ryder.

Program (Monday 18 November 2019):

11:30-11:55 Welcome, with Attending Physician Truls Ryder

11:55-12:20 Cancer treatment with focus on colon cancer, with Professor Kjersti Flatmark

Break

12:30-12:55 “Fight HPV” with Attending Physician Ameli Trope from Kreftregisteret

12:55-13:20 What is anesthesiology? with Professor Ulf Kongsgaard

Break

13:40-14:05 Melanoma, with Attending Physician Anna Winge-Main

14:05-14:30 Plastic surgery – more than just cosmetics! with Head of Clinic and Attending Physician Kim Tønseth

Break

14:40-15:05 Radiology – More than just x-rays! with Attending Physician Marianne Fretheim

15:05-15:30 What is it like to be a patient? with Jeanett Hoel, Chairman of the Norwegian Gynaecological Cancer Society and Attending Physician Kristina Lindemann

15:30-15:45 Summary and practical information concerning clinical rotation, with Attending Physician Truls Ryder

Sign up to OCC monthly newsletter!

The mentors of the student research program at Ullern Upper Secondary School meet the students for the first time.

Meet the mentors

Read the questions and answers from when the students at Ullern Upper Secondary School met their mentors for the very first time.

In the middle of October, 32 students at the researcher program at Ullern Upper Secondary School got to meet their four mentors for the next year. After a short introduction, there were many questions from the students to the mentors. It took an hour and a half before their curiosity settled down and it was time for pizza.

Simone Mester: “I am a former student of Ullern Upper Secondary School and now I am doing a PhD in molecular biology. In the long term, I could imagine working in the private sector developing pharmaceuticals.”

Øyvind Kongstun Arnesen: “I am a doctor and worked many years in Lofoten. After that, I worked some years as a surgeon in an emergency room, before I began working for a large German pharmaceutical company called Boehringer Ingelheim. Eight years ago, I became CEO for Ultimovacs. Ultimovacs are trying to develop the worlds first cancer vaccine.”

Jónas Einarsson: “I am a doctor, and did the first part of my medical degree on Iceland, because my grades weren’t the best. Then, I worked many years as a general practitioner in Lardal, before moving to Oslo and becoming the manager of the first private hospital in Norway. In parallel with this, I did a degree in economy and management at BI. Finally, I became the CEO of Radforsk, who among other things, initiated the Oslo Cancer Cluster Innovation Park and this school collaboration.”

Bjørn Klem: Bjørn is the fourth mentor, but he was unfortunately ill during the first meeting. Janne Nestvold, Laboratory Manager at Oslo Cancer Cluster Incubator, came in his place. Nestvold has a PhD and has worked as a researcher for many years.

 

After the introductions, the teachers at the researcher program, Ragni Fet and Monica Flydal Jenstad held a short presentation of the upcoming work with the mentors.

Then, there were several questions from the audience.  We were really impressed by the amount and quality of the questions, that concerned both education, job opportunities and, research and development, which both Kongstun and Mester are a part of. The questions rained down and the answers came in a session that continued for over an hour and a half. You can read some of them below. Then it was time for some pizza and mingle.

The next time the students and the mentors will meet will be in the beginning of December. The students will meet in the mentors’ workplaces and see with their own eyes what they do on an everyday basis.

 

Questions and answers:

What kind of medical specialisation does Jónas and Øyvind have?

“We are both general practitioners and have not specialised. You do not have to.”

 

What kinds of jobs can you do after you are finished, Simone?

Simone: “I can do a postdoc to become a researcher in academia. I am still a student while I am doing my PhD, but I receive a salary. It is normal to do two postdocs, then you can become group leader or professor. I don’t think I will follow that route, I would much rather work in a private company or start something myself. I think that seems more exciting.”

Jónas: “Simone will get a job immediately in one of our companies if she wants it.”

 

Are there many developments every day to find a cancer vaccine?

Jónas: “It takes time, so the short answer is no.”

 

What is the greatest challenge with the cancer vaccine that Ultimovacs are developing?

Øyvind: “To make it work? A good and difficult question.”

Øyvind explained further about the development and testing of the vaccine at Ultimovacs.

 

What is your PhD about, Simone?

Simone: “I develop technology that prolongs the half-life of medicines. It is a patient-focused PhD, since it is a big inconvenience for the patient to take medicines often, but I hope we can succeed in prolonging the half-life so that patients can take the medicine once a week or once a month.”

 

What should one study if one wants to work with medical development or pharmaceutical development?

Jónas: “Molecular biology, physiology, IT, physics, chemistry, biology, statistics  – there are many opportunities.”

Øyvind: “In our company, we have physiologists, doctors, protein chemists, dentists and pharmacists working right now.”

 

When you went to upper secondary school, did you know that you would be doing what you do today?

Jónas: “I chose the natural science, but did not know anything else.”

Øyvind: “I only knew I wanted to study natural science.”

Simone: “I was thinking about studying a medical degree, but I am happy that I chose molecular biology.”

Janne: “I thought about becoming a researcher and thought it seemed exciting. You should absolutely think widely and not just the easiest solution when you are still in upper secondary school. You will benefit from that when you begin to study at university.”

 

Have you always been interested in biology, or was there something special you saw that made you excited about it? 

Jónas: “Yes, always.”

Øyvind: “Biology in itself is very fascinating. There is so much we do not know, like where memories are stored in the brain, for example. We know very little about how the body works, so that is very fascinating.”

 

The cancer vaccine you are developing, will it work against all cancers or only specific types of cancer?

Øyvind: “It will work to treat and protect against most cancer types.”

 

What did Bjørn do in PhotoCure, the company he worked for before becoming manager for Oslo Cancer Cluster Incubator?

Jónas: “He was Head of Research. He is a very smart guy, and he has also worked a lot with the regulatory side.”

 

Sign up to OCC monthly newsletter

Bente Prestegård from Oslo Cancer Cluster and Ragni Fet from Ullern Upper Secondary School with two of the students in the research program.

Educating the cancer researchers of tomorrow

Ullern Upper Secondary School and Oslo Cancer Cluster are paving the way for students to become the researchers of the future.

A new program has been launched this autumn for Ullern students who wish to learn how researchers work. It will qualify students for university studies and specialise them in biomedical research, technology and innovation. It is the only researcher program for upper secondary school in Norway.

“The researcher program at Ullern will be a place where students are encouraged and guided to become independent students, with a need to explore, an understanding of methods and a desire to learn,” said Ragni Fet, teacher at Ullern Upper Secondary School. “They will learn to gather good and reliable information, they will do research in practice through varied experiments, and they will gain real insight into job opportunities in the research industry.”

The program is a joint initiative between Oslo Cancer Cluster and Ullern Upper Secondary School, who have been collaborating since 2009. This has offered students in the natural sciences, health, media and electricity special opportunities to learn science subjects outside a traditional classroom setting.

“The purpose of launching a researcher program at Ullern Upper Secondary School is to recruit the researchers, scientists and entrepreneurs of the future,” said Bente Prestegård, Project Manager at Oslo Cancer Cluster. “We know that these jobs are needed, and we want to teach students about what it means to be a researcher or entrepreneur. With better insight into the professions, the students will be able to make a safe career choice.”

 

With a passion for science

About 30 students have already begun this unique program at Ullern Upper Secondary School. One of them is Henrikke Thrane-Steen Røkke.

“I chose the researcher program because I personally enjoy studying the natural sciences and innovation, and I wanted more of those subjects. I had entrepreneurship as an elective at secondary school and thought it was a lot of fun. I think it seemed very exciting and wanted to learn more,” Henrikke explained. “I hope I can gain insight into what it is like to work as a researcher. I hope we can see and experience a lot of it in practice and to work in depth with some subjects in certain areas.”

The program is especially well suited for students with an interest in the natural sciences, such as Peder Nerland Hellesylt, who also recently begun the program.

“I applied to this program because I have always had an interest for the natural sciences and mathematics,” Peder said. ”I think this program is very interesting because we aren’t just sitting and writing, but get practical tasks too, for example experiments.”

 

Mixing theory with practice

Ullern Upper Secondary School is located right next to The Norwegian Radium Hospital, The Institute for Cancer Research, The Norwegian Cancer Registry and the Oslo Cancer Cluster Incubator, with its over 30 big and small companies. The students are therefore never far from world class researchers. This offers the unique opportunity to take advantage of the co-localisation and use mentors from the research milieu in the teaching.

“Through the collaboration with Oslo Cancer Cluster, we will obtain external lecturers to the class rooms; bring the students to multiple, exciting innovation companies and laboratories; and the students will attempt real research experiments themselves. We are raising the level and are ambitious for the sake of the students,” Ragni Fet said.

 

Sign up to OCC newsletter

Emmy and Benedicte learned about research into neuroscience and how to use modern medical technology, such as CRISPR, when on work placement with researcher Marianne Fyhn and her colleagues at the University of Oslo. Photo: Monica Jenstad

Learning about the human brain

Oslo Cancer Cluster and Ullern Upper Secondary School arranged a work placement for students to learn about neuroscience at the University of Oslo.

Four biology students from Ullern Upper Secondary School spent two great days on work placement with some of the world’s best neuroscientists at the University of Oslo. In Marianne Fyhn’s research group, the students tried training rats and learned how research on rats can provide valuable knowledge about the human brain.

The Ullern students, Benedicte Berggrav, Lina Babusiaux, Maren Gjerstad Høgden and Emmy Hansteen, first had to dress in green laboratory clothes, hairnets and gloves. They also had to leave their phones and notepads behind, before enterring the animal laboratory where Marianne Fyhn and her colleagues work. Finally, they had to walk through an air lock that blew the last remnants of dust and pollution off them.

On the other side was the most sacred place for researchers: the newly refurbished animal laboratory. It is in the basement of Kristine Bonnevies Hus on the University of Oslo campus. We used to call it “Bio-bygget” (“the bio-building”) when I studied here during the ‘1990s.

 

Researcher Kristian Lensjø showed the four excited biology students into the most sacred place: the animal lab.

Researcher Kristian Lensjø showed the four excited biology students into the most sacred place: the animal lab.

It is the second day of the students’ work placement with Marianne. The four biology students, who normally attend the second year of Ullern Upper Secondary School, have started to get used to their new, temporary jobs. They are standing in one of the laboratories and looking at master student Dejana Mitrovic as she is operating thin electrodes onto the brain of a sedated rat. PhD student Malin Benum Røe is standing behind Dejana, watching intently, giving guidance and a helping hand if needed.

“We do this so we can study the brain cells. We will also find out if we can guide the brain cells with weak electrical impulses. This is basic scientific research. In the long term, the knowledge can help to improve how a person with an amputated arm can control an artificial prosthetic arm,” Marianne explained.

“The knowledge can help to improve how a person with an amputated arm can control an artificial prosthetic arm.”

Dejana needs to be extremely precise when she connects the electrodes onto the rat’s brain. This is precision work and every micrometre makes a difference.

 

Training rats

The previous day, Maren, Benedicte, Lina and Emmy helped to train the rat on the operating table on a running course. Today, the Ullern students will train the other rats that haven’t had electrodes surgically connected to their brains yet.

“We will train the rats to walk in figures of eight, first in one direction and then the other”, the students explained to me.

We remain standing in the rat training room for a while, talk with Dejana and train some of the rats. Dejana tells me that the rats don’t have any names. After all, they are not pets, but they are cared for and looked after in all ways imaginable.

“It is very important that they are happy and don’t get stressed. Otherwise, they won’t perform the tasks we train them to do,” says Dejana. She and the other researchers know the animals well and know to look for any signs that may indicate that the rats aren’t feeling well.

“It is very important that they are happy and don’t get stressed.”

I ask the students how they feel about using rats for science.

“I think it is completely all right. The rats are doing well and can give us important information about the human brain. It is not okay when rats are used to test make-up and cosmetics, but it is a whole different matter when it concerns important medical research,” says Emmy and the other biology students from Ullern nod in agreement.

 

Understanding the brain

Marianne is the head of the CINPLA centre at the University of Oslo, where Maren, Benedicte, Lina and Emmy are on work placement for two days. Four other Ullern students, Henrik Andreas Elde, Nils William Ormestad Lie, Hans Christian Thagaard and Thale Gartland, are at the same time on a work placement with Mariannes research colleague, Professor of Physics Anders Malthe-Sørenssen. They are learning about methods in physics, mathematics and programming that help researchers to better understand the brain.

“CINPLA is an acronym for Centre for Integrative Neuroplasticity. We try to bring together experimental biology with calculative physics and mathematics to better understand information processing in the brain and the brain’s ability to change itself,” says Marianne.

Physics, mathematics and programming are therefore important parts of the researcher’s work when analysing what is happening in the rat’s brain.

If you think that research on rats’ brain cells sounds familiar, then you are probably right. Edvard and May-Britt Moser in Trondheim received the first Norwegian Nobel Prize in Medicine in 2014. The award was given to them for their discovery of a certain type of brain cells, so called grid cells. The grid cells alert the body to its location and how to find its way from point A to point B.

Marianne did her PhD with Edvard and May-Britt, playing an essential role in the work that led to the discovery of the grid cells. Marianne was therefore very involved in Norway securing its first Nobel Prize in Medicine.

 

The dark room

Another room in the animal section is completely dark. In the middle of the room, there is an enormous box with various equipment. In the centre of the box, there is a little mouse with an implant on its head.

In this test room, there is an advanced microscope. It uses a laser beam to read the brain activity of the mouse as it alternates between running and standing still on a treadmill.

The researcher Kristian Lensjø is back from a longer study break at the renowned Harvard University and will use some of the methods he has learned.

“I will train the mouse so that it understands that for example vertical lines on a screen mean reward and that horizontal lines give no reward. Then I will look at which brain cells are responsible for this type of learning,” says Kristian.

The students stand behind Kristian and watch the mouse and the computer screen. When the testing begins, they must close the microscope off with a curtain so that the mouse is alone in the dark box. Kristian assures us that the mouse is okay and that he can see what the mouse is doing through an infra-red camera.

“This room and the equipment is so new, we are still experiencing some issues with the tech,” says Marianne. But Christian fixes the problem and suddenly we see something on the computer screen that we have never seen before. It is a look into the mouse’s brain while it runs on the treadmill. This means that the researchers can watch the nerve cells as the mouse looks at vertical and horizontal lines, and detect where the brain activity occurs.

 

Research role models

The students from Ullern know they are lucky to see how cutting-edge neuroscience is done in real life. Marianne and her colleagues are far from nobodies in the research world. Bente Prestegård from Oslo Cancer Cluster and Monica Jenstad, the biology teacher at Ullern who coordinates the work placements, made sure to tell the students beforehand.

“This is a fantastic and unique opportunity for students to get a look into science on a high international level. They can see that the people behind the research are nice and just like any normal people. When seeing good role models, it is easier to picture a future in research for oneself,” says Monica.

“This is a fantastic and unique opportunity for students to get a look into science on a high international level.”

Monica and Marianne have known each other since they were master students together at the University of Tromsø almost twenty years ago.

“I know Marianne very well, both privately and professionally. She is passionate about her research and about dissemination and recruitment. She also works hard to create a positive environment for her research group. Therefore, it was natural to ask Marianne to receive the students and it wasn’t difficult to get her to agree,” says Monica.

Back in the first operating room, Dejana and Malin are still operating on the rats. They will spend the entire day doing this. It takes time when the equipment needs to be found and sterilised, the rats need to be sedated and then operated on as precisely as possibly. It is past noon and time for lunch for Marianne, Kristian and the Ullern students on work placement.

Before I leave them outside Niels Henrik Abels Hus at the Oslo University Campus, I take a picture to remember the extra-ordinary work placement. And not least: to store a picture of the memory in my own brain.

 

Finally, time for lunch! From the left: Emmy Hansteen, Benedicte Berggrav, researcher Marianne Fyhn, Lina Babusiaux, Maren Gjerstad Høgden and researcher Kristian Lensjø. Photo: Elisabeth Kirkeng Andersen.

Finally, time for lunch! From the left: Emmy Hansteen, Benedicte Berggrav, researcher Marianne Fyhn, Lina Babusiaux, Maren Gjerstad Høgden and researcher Kristian Lensjø. Photo: Elisabeth Kirkeng Andersen.

 

Sign up to OCC newsletter