News regarding Oslo Cancer Cluster

Learning from the Americans

Ole Dahlberg, CEO of Curida Diatec, reveals where he thinks the health industry is headed, why Norway needs to own its medical manufacturing, and how we might learn from the Americans.

“I wish that we can make things happen faster here in Norway. We can learn from the Americans that you don’t need to have all details in place to get going. If we commit to invest in the health industry, it will not go wrong.”

Ole Dahlberg is the new CEO of Curida Diatec. He has more than 25 years’ experience from the life sciences. He was Managing Director for Thermo Fisher Scientific Norway for eight years, and later Vice President for Thermo Fisher working out of California, USA. He has also co-founded three start-up companies, and sits on several boards, including Oslo Cancer Cluster, Nadeno, DoMore Diagnostics, and Caedo Oncology.

“If we commit to invest in the health industry, it will not go wrong.”

Why does this accomplished international business leader wish to invest his time in Norway?

“There is a lot of great research being done here, but it needs to translate to value creation for companies, and we need more commercial partners to help put products on the market.”

Is Norway prepared?

This is where Curida comes into the picture. Curida is a Norwegian company that helps biotech companies that want to scale up manufacturing, or that want to transfer their manufacturing and need help with quality improvement.

“Norway is at a crossroads when it comes to national preparedness.”

“Curida is at an inflection point right now and will need to make significant investments to upgrade. There is interest to invest in the company, especially from international investors. At the same time, Norway is at a crossroads when it comes to national preparedness. The government needs to make a strategic choice about which manufacturing processes they want to control. I hear many stakeholders calling for a clear direction from the government,” said Dahlberg.

A missed opportunity

Dahlberg has been in a similar situation before. When he was Managing Director for Thermo Fisher Scientific, the company together with Novartis wanted to invest in production facilities for cell therapies in Norway. There were already advanced laboratories in use at the Norwegian Institute of Public Health.

“This demonstrated we could do it. But we were not able to reach an agreement with the government on how to transfer technology and scale the business on reasonable terms.”

Instead, Thermo Fisher Scientific set up production facilities in Vilnius, Lithuania, where they received better support from the government. Today, the Vilnius site is scaling fast with 1 900 employees that are manufacturing world-class products and building sought after competence.

“The pandemic demonstrated the importance of manufacturing control and building key competence.”

“Back then it was less important to me as an international industry leader; I had to make the right decision for Thermo Fisher Scientific. As a Norwegian however, this was clearly a missed opportunity. The pandemic demonstrated the importance of manufacturing control and building key competence.”

Time to take a risk!

The health industry in Norway has grown rapidly the last decade. A new generation of up-and-coming researchers are eager to take a chance and create companies. More start-ups are spun out from research than before. There have already been successful examples of companies on the stock market.

“The problem is that many of the companies don’t scale. We need politicians to work closely with the industry and innovators. Politicians also need to enable cross-ministry collaborations and initiatives, and finally agree to a common purpose and a few goals. We have a good foundation in Norway with much experience in process industry, and tradition and reputation for our ability to work internationally.”

“We need politicians to work closely with the industry and innovators.”

Dahlberg also thinks the politicians should start promoting Norway as a place for international collaboration and technological innovation, as well as a country that attracts life science talents.

“Companies have difficulties finding the right talents. I think politicians should make sure students want to come here and that the networks attract more high-skilled people. We need both young and old, different nationalities and of all competencies. We must help talent immigrants manage the complex tax situation when they move to Norway.”

A Norwegian success story

Curida is one of the recent success stories from the Norwegian health industry. The company has had an incredible development over the last eight years, increasing its annual turnover from NOK 50 million in 2015 to NOK 200 million today. The company has already lined up agreements with international companies to increase that number significantly in the next 18 months.

“It is crucial for the Norwegian government to support the industry now if they want to have influence and necessary control on key manufacturing in Norway.”

“Curida is a fully owned Norwegian company, and it is no longer a start-up, but is scaling fast. We have signed new contracts and have more customers coming in. We will invest in new technologies, upgrade our production processes, build competence and organisation, and initiate great collaborations. It is crucial for the Norwegian government to support the industry now if they want to have influence and necessary control on key manufacturing in Norway,” said Dahlberg.

As difficult as landing a plane …

When it comes to manufacturing medicines, the tech transfer process is extremely time-consuming, complicated, and unpredictable. Projects can run out of time, costs can increase, and the customer might lose its window to the market or have to take existing products off the market.

At the Curida site in Elverum, there are over 130 employees spanning 20 nationalities, who all hold unique competencies in this field. Some of them have been with the company since its establishment almost 30 years ago.

“The highly skilled employees make Curida great at tech transfer. It is a bit like landing an airplane. There are a lot of moving parts, and many things can go wrong. Curida has done an impressive number of tech transfers and shown every single time that we can deliver on quality, time, and price.”

It is often in the tech transfer processes that small companies struggle.

“We do not have a traditional pharma industry, like in Sweden, and that is why we need to scale fast.”

“If the companies manage to do the right job and surround themselves with the right partners, they can quickly enter clinical phase. This is where Norway needs to expand the value chain. We do not have a traditional pharma industry, like in Sweden, and that is why we need to scale fast,” said Dahlberg,

A growing innovation milieu

Dahlberg has been on the board of Oslo Cancer Cluster for the last seven years and followed how the clusters have made an impact on Norwegian innovation.

“Oslo Cancer Cluster has been a pioneer in this field, with a clear oncology focus. They have started their own incubator and with their close connection to Radforsk Investment Fund, we see many exciting companies coming through the organisation. Oslo Cancer Cluster is an extremely important facilitator, represents diverse members and has become a well-recognized international brand.

“The challenge going forward will be to understand the value proposition to our members and listen closely to what they need. It is an exciting road we have ahead of us, and I look forward to contributing to the organisation’s future direction.”

More personalised breast cancer screening

A new clinical pilot offers personalised breast cancer screening to Norwegian women.

A new clinical pilot will investigate how women can receive more personalised breast cancer screening. Currently, women in the age group 50-69 are invited to mammogram screenings every second year in Norway, but 20 percent of breast cancer cases are diagnosed among younger women.

“This ‘one size fits all’ approach does not take into account the different breast cancer risks of individual women. A more personalised screening program might be beneficial for both women and society, both in terms of increased surveillance of persons at higher risk for breast cancer, as well as more targeted use of resources. My motivation as a breast radiologist is to work for a high-quality, evidence-based screening program for breast cancer, and this study is an exciting contribution in that respect,” said Tone Hovda, senior radiologist at Vestre Viken Hospital Trust, where the study is running.

Tone Hovda, senior radiologist, Vestre Viken Hospital Trust

Using innovative DNA analysis

Participants of the study will submit a saliva sample, which is sent to Estonia for a genetic data analysis done by the Estonian medical technology company and healthcare service provider Antegenes that has developed the genetic test AnteBC. The AnteBC test is a CE-certified medical device.

The test is used to map a range of gene variants that individually don’t give increased risk for breast cancer, but where the combination of several genes can result in an increased risk. This is called polygenic risk score (PRS) and has never been used in screening programmes in Norway before.

Saliva shows risk of breast cancer

The results from the test will show if the participant has an elevated genetic risk for breast cancer. If it doesn’t, the participant will be recommended to follow the ordinary screening programme for breast cancer in Norway.

If the test shows an elevated risk for breast cancer, the participant will be offered a control scheme, which may include a recommendation of starting regular mammography before they turn 50 years old and/or go to mammography more often than every two years.

“The study analyses a woman’s genetic predisposition to the development of breast cancer, and based on that, provides personalized clinical recommendations for the prevention and early detection of disease. In the pilot study, both a woman’s polygenic risk and, if necessary, the presence of rare single genes that increase the risk of breast cancer will be evaluated,” commented Peeter Padrik, CEO, Antegenes.

Participants will also answer a questionnaire to give background information, such as family history. If there is suspicion of elevated risk of hereditary familial disease, the participant may be offered genetic counselling and extended genetic testing according to current clinical practice.

Towards personalised screening

This initiative is part of the implementation research project AnteNOR, which aims to investigate how it will be possible to implement a more personalised screening programme for breast cancer in Norway, based on the individual’s genetic risk for disease.

The project partners are Oslo University Hospital, the University of Oslo, Vestre Viken Hospital Trust, Oslo Cancer Cluster and Antegenes. It has received funding from The Norway Grants Green ICT programme and runs between 2021-2024.

The clinical trial has received approval from the regional ethics committee and is registered in the database clinicaltrial.gov.

Project partners:

Funded by:

Meet our newest members

Get to know the latest additions to our cancer cluster a bit better!

Oslo Cancer Cluster is a member organization with a vision to accelerate the development of novel cancer diagnostics and therapies to improve patients’ lives.

We have about 100 members, spanning the whole oncology value chain. These include university hospitals, research institutions, patient organisations, companies in pharmaceutical development, biotech, technology, human resources, recruitment, legal services and more.

We are proud to announce the following companies have recently joined our cluster: Augere Medical, Culture Intelligence, Diffia, Expert Analytics, Miphic and PharmaRelations.

We asked them to introduce themselves further and below you can read what they said.

Developing AI-based decision support systems

“Augere Medical develops AI-based decision support systems for medical video examinations. Our first product is real-time support to highlight polyps during colonoscopy examinations. Such polyps have the potential to develop into cancer, and it is therefore important to uncover as many as possible during the examination.

“Augere Medical looks forward to benefit from the extensive knowledge present in the Oslo Cancer Cluster network. We also look forward to share our knowledge and experiences from developing a medical deep tech product.”

Andreas Petlund, Chief Executive Officer, Augere Medical

Optimizing the work culture with value-driven actions

“Our purpose is to radically improve how people work together. In uncertain times, working together have never been more important. We help organizations to measure, identify and optimize their culture trough values driven actions.

“Our contributions to the group (cluster) will be to use our competency around people, collaboration, and culture-capital, to drive high performance and business growth.”

Tone S. Ringstad, Founder and CEO, Cultural Intelligence

Improving the care and quality of life for cancer patients

“Diffia is a digital health company working to improve the care and quality of life for cancer patients, by helping hospitals and municipalities provide more care at home. We also provide clinicians with a seamlessly integrated experience to coordinate care better and more efficiently.

“We view Oslo Cancer Cluster as a unique organization that brings together the oncology value chain, both public and private, to drive innovation through collaboration and knowledge sharing. As a member, we aim to learn from and contribute to the cluster’s efforts in enhancing the lives of people with cancer.”

Dr. Petter Risøe, Chief Operating Officer and Co-Founder, Diffia

Solving problems in technology development

“Expert Analytics is a private research company advertised as a haven for academics passionate about problem-solving. At Expert Analytics, we offer consultancy services to assist the development of technologies in the biomedical sector through data analytics, pipeline automation, and fundamental research.

“Our scientists have diverse scientific backgrounds covering molecular biology, neuroscience, and nuclear physics and are ready to apply their knowledge to novel solutions for complex problems.”

Sebastian Franco Ulloa, Ph.D. Principal Data Analyst, Biotechnology Division, Expert Analytics

Delivering mitochondrial testing for cancer patients

“Mitochondria produce essentially all the energy that our bodies need to live. Despite that we still don’t have the technology to test mitochondrial function in clinics. Miphic is a solution for that. Mitochondria in cancer cells are very different in comparison to healthy cells. Miphic has the first-ever proof-of-concept that mitochondria of a cancer patient can be easily tested, and that this information can be used for personalized anti-cancer therapy.

“Miphic has a revolutionary technology that will allow to test mitochondria in clinics. Working together with the many partners from Oslo Cancer Cluster, we will tune and diversify our platform for the exact clinical needs of various cancer treatments. Miphic wants to learn the requirements of pharma partners and clinical personnel to deliver a streamlined and cost-effective mitochondrial screening for real world cancer patients.”

Gennady Nikitin, PhD, founder and CEO, Miphic

Delivering the best candidates in Nordic life science

“PharmaRelations is a full service partner for the Life Science industry. We support Nordic Life Science through all phases of development. We deliver the best candidates within recruitment and interim solutions. We have more than 70 years experience from different Life Science companies from all sectors commercial, medical, regulatory, QA, PV. Call me for an non-binding conversation.”

Sverre Slaastad, Country Manager Norway, PharmaRelations

 

 

Please visit the Membership Overview to see all members of Oslo Cancer Cluster.

Two men and two women looking into the camera wearing dressed up clothes

Klynger samarbeider om å styrke investor-arbeidet

Scroll down for an English version of this article.

Klyngene har en unik rolle i å øke private investeringer til norsk næringsliv. Nå går fem norske klynger innen helse og livsvitenskap sammen om investorarbeid og internasjonalisering slik at enda flere norske bedrifter skal lykkes. Prosjektet ledes av The Life Science Cluster.

Sammen med Oslo Cancer Cluster, Norway Health Tech, Norwegian Smart Care Cluster og Biotech North skal The Life Science Cluster sørge for en samlet innsats for å presentere norske bedrifter til nye og eksisterende investorer klyngene har kontakt med. Prosjektet er støttet av Viken fylkeskommune over to år.

– Klyngene har allerede et godt samarbeid på flere områder. Nå styrker vi dette ytterligere, og systematiserer og samordner arbeidet med investorer og internasjonalisering. Prosjektet vil lage en metodikk for å presentere norske selskaper for nordiske og internasjonale investorer. Målet er at enda flere bedrifter skal lykkes når vi samarbeider, sier Hanne Mette Dyrlie Kristensen, CEO, The Life Science Cluster.

Urolige markeder og lavere investeringsvilje

Livsvitenskap og helseteknologi er motsykliske næringer og skaper løsninger verden trenger i omstilling og utfordrende tider, men til og med denne typen selskaper opplever at investorene har færre midler tilgjengelig enn tidligere.

– Prosjektet har vært planlagt en god stund, men timingen er dessverre svært god nå. Vi ser at urolige finansmarkeder gjør det vanskeligere for selskaper å hente nok investeringer til å følge planlagte utviklingsløp. Det er alvorlig. Løsninger som møter mange av de store helseutfordringene som kommer i årene framover, risikerer å ikke blir realisert fordi bedriftene mangler midler, sier Lena Nymo Helli, CEO, Norway Health Tech.

Lange og kompliserte utviklingsløp

Bedrifter som utvikler løsninger innen helse og livsvitenskap må gjennom lange, kompliserte og kapitalintensive utviklingsløp med høy risiko. Det betyr at selskapene har behov for ulike investorer til ulik tid i utviklingsløpet – helt fra forskning til produktlansering.

Selskapene trenger derfor investorer med ulik kompetanse, med ulik markedsforståelse og ulike nettverk i ulike markeder. Selskapene finner noen slike investorer i Norge, men langt fra nok til å bringe produktene sine helt frem til markedet. Klyngene med sine solide internasjonale nettverk er svært viktige for at selskapene skal finne riktig kompetanse til riktig tid i utviklingsløpet.

– Vi vet at selskapene ikke bare trenger penger, men kompetent kapital, spesielt i begynnelsen av utviklingsløpet. Da er det svært viktig å finne riktig investor. Alle klyngene legger til rette for dette og har gjort det i flere år. Gjennom dette samarbeidet øker vi både tilgangene til antall investorer og profesjonaliserer måten vi presenterer selskapene våre til dem, sier Ketil Widerberg, General Manager, Oslo Cancer Cluster.

– Helseteknologiselskaper utvikler nye løsninger, men det tar ofte lang tid å få dem tatt i bruk i helsetjenesten. Kompetente investorer kan bringe kapital og erfaring om hva som har fungert i andre land, og bidra til at selskapene både står ut løpet, og får nye løsninger fortere til pasienter, helsevesen og samfunnet, sier Arild Kristensen, CEO, Norwegian Smart Care Cluster.

Banebrytende klyngesamarbeid

Klynger er døråpnere for privat kapital. De fem klyngene samarbeider i dette prosjektet om å utvikle eksisterende investornettverk, samt å kartlegge og mobilisere investorer som har interesser innen og på tvers av teknologiområder. På denne måten ønsker de samarbeidende klyngene å øke interessen nasjonalt og internasjonalt for norske teknologier og selskaper.

– Våre medlemsselskap konkurrerer i et internasjonalt marked. Når investorer søker etter gode investeringsprosjekter, er de i utgangspunktet ikke opptatt av hvilket land prosjektet har opprinnelse i. De er i alle fall ikke opptatt av hvilke deler av et norsk økosystem det tilhører. Vi er svært bevisste på at vi med dette samler oss som en norsk kraftfull satsing for livsvitenskap og helseteknologi – som har mange interessante løsninger for de rette investorene, både norske og internasjonale. Det sier Line Kjelstrup, Cluster Manager, Biotech North.

Viktig eksportområde med stort vekstpotensial

Norge står overfor en stor omstilling, og har behov for nye eksportområder. Helseteknologi og livsvitenskap er allerede et betydelig eksportområde i Norge, men har potensial for å bli mye større. I 2021 eksporterte helseindustrien for 27 mrd. i 2021. Det viser en rapport fra Menon om verdien av norsk helseindustri fra 2022. Klyngene var derfor sentrale i arbeidet med felles innspill fra bransjen som på slutten av 2022 ble sendt til Nasjonalt eksportråd.

– Vi må tiltrekke flere investeringer til Norge, slik at mer av verdiskapingen av norske innovasjoner forblir i Norge. Slik kan de bedriftene vi nå jobber med nå bidra til at Norge når målet om doblet fastlandseksport innen 2030, sier Hanne Mette Dyrlie Kristensen, CEO, The Life Science Cluster.

 

Inven2 som er teknologioverføringskontor for Helse Sør-Øst, Universitetet i Oslo og Oslo Universitetssykehus, SPARK Norway som er del av UiO Livsvitenskap, og Veksthuset for verdiskapning ved UiO er også partnere i prosjektet.

Inkubatorene Aleap, Sharelab, OCC Incubator og Aggrator er klyngenes faste samarbeidspartnere og støtter prosjektet.

 

Metodikk for samordnet investorarbeid for livsvitenskap og helseteknologi

Et felles prosjekt fra helse- og livsvitenskapsklyngene i Norge.

Ledet av The life Science Cluster

Partnere: Oslo Cancer Cluster, Norway Health Tech, Norwegian Smart Care Cluster og Biotech North

Tilskudd fra Viken fylkeskommune over to år

Klyngene skal samarbeide om å presentere norske selskaper for nordiske og internasjonale investorer.

 

Clusters collaborate to strengthen work with investors

The clusters have a unique role to increase private investments in Norwegian industry. Now five Norwegian clusters in health and life science are teaming up to work with investors and internationalization, so that even more Norwegian companies will succeed. The project is led by The Life Science Cluster.

Together with Oslo Cancer Cluster, Norway Health Tech, Norwegian Smart Care Cluster and Biotech North, The Life Science Cluster will ensure a coordinated effort to present Norwegian companies to new and existing investors that the clusters are in contact with. The project is supported by Viken County for the duration of two years.

“The clusters already collaborate well in several areas. Now we are strengthening this further, and systematizing and coordinating the work with investors and internationalization. The project will create a methodology for presenting Norwegian companies to Nordic and international investors. The goal is that even more companies will succeed when we collaborate,” said Hanne Mette Dyrlie Kristensen, CEO, The Life Science Cluster.

Volatile markets and lower interest to invest

Life science and health technology are countercyclical industries and create solutions that the world needs during transitional and challenging times, but even these types of companies experience that investors have less funds available than before.

“The project has been planned for a while, but the timing is unfortunately very good now. We see that volatile financial markets make it more difficult for companies to raise enough funds to follow their planned course of development. This is serious. Solutions that answer many of the big health challenges in the years to come, run the risk of not being realized because companies lack funds,” said Lena Nymo Helli, CEO, Norway Health Tech.

Long and complicated courses of development

Companies that develop solutions in health and life science need to go through long, complicated and capital intensive courses of development with high risk. This means that the companies need different investors at different times during the course of development – all the way from research to product launch.

The companies therefore need investors with different competencies, different market understandings and contact networks in different markets. The companies find such investors in Norway, but far from enough to bring their products all the way to market. The clusters with their solid international networks are very important for the companies to find the right competency at the right time in their courses of development.

“We know that companies not only need funds, but also competent capital, especially in the beginning of the course of development. Then it is extremely important to find the right investor. All the clusters facilitate this and have been doing so for years. Through this collaboration, we are increasing both the access to the number of investors and professionalizing the way we present companies to them,” said Ketil Widerberg, general manager, Oslo Cancer Cluster.

“Health technology companies develop new solutions, but it often takes a long time to implement them in the health service. Competent investors can bring capital and experience about what has worked in other countries, and contribute to the companies getting through the course of development, and get new solutions faster to the patients, health sector and society,” said Arild Kristensen, CEO, Norwegian Smart Care Cluster.

Groundbreaking cluster collaboration

Clusters open the doors to private capital. The five clusters collaborate in this project on developing the existing investor networks, as well as mapping and mobilizing investors that have an interest in and across technology sectors. In this way the collaborating clusters wish to increase the interest nationally and internationally for Norwegian technologies and companies.

“Our member companies compete in an international market. When investors look for good investment projects, they are not too concerned with which country the project originates from. They are in any case not concerned with which parts of the Norwegian ecosystem it belongs to. We are very aware that we are gathering ourselves as one Norwegian strong initiative for life science and health technology – that has many interesting solutions for the right investors, both Norwegian and international,” said Line Kjelstrup, Cluster Manager, Biotech North.

Important area for export with big growth potential

Norway faces a huge transition, and needs new areas of export. Health technology and life science are already two important export industries in Norway, but have the potential of becoming even larger. The health industry exported for NOK 27 bn in 2021, according to a 2022 report from Menon Economics about the value of the health industry. The clusters were central in the creation of a coordinated response from the industry in the end of 2022, which was sent to the National Council for Export.

“We need to attract more investments to Norway, so that more of the value creation from Norwegian innovations stay in Norway. In that way, the companies we work with now, can contribute to Norway reaching the goal of doubled mainland exports before 2030,” said Hanne Mette Dyrlie Kristensen, CEO, The Life Science Cluster.